Concept design: Dr. Hirak K Patra and Sachin Mishra
On 5 September 2018, the research group headed by Professor Hirak K. Patra from University of Cambridge has reviewed the quest for guided nanoparticle-protein interactions. The review article entitled “Inner-View of Nanomaterial Incited Protein Conformational Changes: Insights into Designable Interaction” has been published in Research (Research 2018 Article ID: 9712832 DOI: 10.1155/2018/9712832). https://spj.sciencemag.org/research/2018/9712832/.
In natural system, interfacial molecular interactions are at the centre of protein functions and are reconciled by their unique structure-function relationship. Inspired by their responsive mechanisms and our increased capability to manipulate matter at the nanoscale, new Nano-bio interfaces are emerging.
In this report, we discuss mechanistic view of NM-protein interactions and recapitulate the underlying chemistry behind the formation of such emerging macro-molecular assemblies. This article takes the opportunity to propose a novel perspective, tightly coupled with principles from artificial intelligence (AI), to predict and design facilitated interactions beneficial for a targeted system. This report will be extremely important to understand fundamental interactions of Nano surfaces in biological system for both minimizing the risk and design new targeted functions.
Tag: Biology and life sciences